ABSTRACT
Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. In a population-based 7-year prospective study, we genotyped 222 individuals (72 males and 150 females, aged 56.2 ± 10.5 years) with normal glucose tolerance at baseline. In the study population, we found that the minor allele frequency was 0.05 for SNP rs7903146 and 0.03 for SNP rs12255372. No significant allele or genotype association with glucose intolerance incidence was found for either SNP. Haplotypes were constructed with these two SNPs and three haplotypes were defined: CG (frequency: 0.94), TT (frequency = 0.027) and TG (frequency = 0.026). None of the haplotypes provided evidence for association with the incidence of glucose intolerance. Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. In conclusion, in Japanese-Brazilians, a population with a high prevalence of type 2 diabetes, common TCF7L2 variants did not make major contributions to the incidence of glucose tolerance abnormalities.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Glucose Intolerance/genetics , Polymorphism, Single Nucleotide , /genetics , Asian People , Brazil , Gene Frequency , Genetic Predisposition to Disease , Genotype , Glucose Intolerance/ethnology , Incidence , Prospective StudiesABSTRACT
Os autores apresentam os resultados do tratamento em 11 pacientes com aneurismas múltiplos. A conduta utilizada foi o tratamento cirúrgico de todos os aneurismas diagnosticados: em 8 pacientes a cirurgia total foi possível em um estágio e, apenas 3 pacientes necessitaram de uma segunda cirurgia para a clipagem dos aneurismas nao abordados na primeira cirurgia. Os autores sugerem a adoçao de uma conduta cirúrgica mais radical no tratamento dos aneurismas múltiplos.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Intracranial Aneurysm/surgery , Subarachnoid Hemorrhage/surgeryABSTRACT
Se realiza en el presente estudio un seguimiento prospectivo de ocho pacientes con diagnóstico nuevo de Colitis Ulcerativa idiopática asociada con manifestaciones extraintestinales encontrandose hepatopatía en el 50 por ciento de los casos, los cuales se relacionaron con hipocratismo digital (100 por ciento), monocitosis (75 por ciento), fosfatasa alcalina aumentada (75 por ciento), seudopólipos intestinales (75 por ciento), evolución de la enfermedad mayor de tres anos (75 por ciento) y sexo femenino